| Common Name: | ACETONITRILE, REAGENT, ACS |
| Manufacturer: | SPECTRUM CHEMICALS & LABORATORY PRODUCTS |
| SDS Revision Date: | 6/6/2019 |
| SDS Format: | No Format Specified |
| Item Number(s): | 39H162 |
| Manufacturer Model Number(s): |
SDS Table of Contents
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SPECTRUM(R*)
CHEMICAL MFG CORP
S
ISO 9001-2015 REGISTERED
SAFETY DATA SHEET
PREPARATION DATE: 1/17/2014
REVISION DATE: 6/6/2019
REVISION NUMBER: G3
| 1. IDENTIFICATION |  |
PRODUCT IDENTIFIER:
PRODUCT CODE: A1030
PRODUCT NAME: ACETONITRILE, REAGENT, ACS
OTHER MEANS OF IDENTIFICATION:
SYNONYMS:
CYANOMETHANE
CYANURE DE METHYL (FRENCH)
ACETONITRILE (FRENCH)
ETHANENITRILE
ETHYL NITRILE
METHANE, CYANO-
METHANECARBONITRILE
METHYL CYANIDE
ACETONITRILO (SPANISH)
CAS #: 75-05-8
RTECS # AL7700000
CI#: NOT AVAILABLE
RECOMMENDED USE OF THE CHEMICAL AND RESTRICTIONS ON USE:
RECOMMENDED USE: SOLVENT. CHEMICAL INTERMEDIATE. IN ORGANIC SYNTHESIS.
USES ADVISED AGAINST: NO INFORMATION AVAILABLE
SUPPLIER:
SPECTRUM CHEMICAL MFG. CORP
14422 SOUTH SAN PEDRO ST.
GARDENA, CA 90248
(310) 516-8000
ORDER ONLINE AT: HTTPS://WWW.SPECTRUMCHEMICAL.COM
EMERGENCY TELEPHONE NUMBER:
CHEMTREC: 1-800-424-9300
CONTACT PERSON: TOM TYNER (USA - WEST COAST)
CONTACT PERSON: IBAD TIRMIZ (USA - EAST COAST)
| 2. HAZARDS IDENTIFICATION | |
CLASSIFICATION:
THIS CHEMICAL IS CONSIDERED HAZARDOUS BY THE 2012 OSHA HAZARD COMMUNICATION
STANDARD (29 CFR 1910.1200)
CONSIDERED A DANGEROUS SUBSTANCE OR MIXTURE ACCORDING TO THE GLOBALLY
HARMONIZED SYSTEM (GHS)
ACUTE TOXICITY - ORAL: CATEGORY 4
ACUTE TOXICITY - DERMAL: CATEGORY 4
ACUTE TOXICITY - INHALATION (GASES): CATEGORY 4
ACUTE TOXICITY - INHALATION (VAPORS): CATEGORY 4
ACUTE TOXICITY - INHALATION (DUSTS/MISTS): CATEGORY 4
SERIOUS EYE DAMAGE/EYE IRRITATION: CATEGORY 2A
FLAMMABLE LIQUIDS: CATEGORY 2
LABEL ELEMENTS:
DANGER
HAZARD STATEMENTS:
HARMFUL IF SWALLOWED
HARMFUL IN CONTACT WITH SKIN
HARMFUL IF INHALED
CAUSES SERIOUS EYE IRRITATION
HIGHLY FLAMMABLE LIQUID AND VAPOR
EXCLAMATION MARK
FLAME
HAZARDS NOT OTHERWISE CLASSIFIED (HNOC): NOT APPLICABLE
OTHER HAZARDS: CAUSES MILD SKIN IRRITATION
PRECAUTIONARY STATEMENTS - PREVENTION:
WASH FACE, HANDS AND ANY EXPOSED SKIN THOROUGHLY AFTER HANDLING
DO NOT EAT, DRINK OR SMOKE WHEN USING THIS PRODUCT
WEAR PROTECTIVE GLOVES/PROTECTIVE CLOTHING/EYE PROTECTION/FACE PROTECTION
AVOID BREATHING DUST/FUME/GAS/MIST/VAPORS/SPRAY
USE ONLY OUTDOORS OR IN A WELL-VENTILATED AREA
KEEP AWAY FROM HEAT/SPARKS/OPEN FLAMES/HOT SURFACES. - NO SMOKING
KEEP CONTAINER TIGHTLY CLOSED
GROUND CONTAINER AND RECEIVING EQUIPMENT
USE EXPLOSION-PROOF EQUIPMENT
USE ONLY NON-SPARKING TOOLS
TAKE PRECAUTIONARY MEASURES AGAINST STATIC DISCHARGE
PRECAUTIONARY STATEMENTS - RESPONSE:
IN CASE OF FIRE: USE CO2, DRY CHEMICAL, OR FOAM TO EXTINGUISH.
IF IN EYES:
RINSE CAUTIOUSLY WITH WATER FOR SEVERAL MINUTES. REMOVE CONTACT LENSES, IF
PRESENT AND EASY TO DO. CONTINUE RINSING.
IF EYE IRRITATION PERSISTS: GET MEDICAL ATTENTION.
CALL A POISON CENTER OR PHYSICIAN IF YOU FEEL UNWELL
WASH CONTAMINATED CLOTHING BEFORE REUSE
IF ON SKIN (OR HAIR):
REMOVE/TAKE OFF IMMEDIATELY ALL CONTAMINATED CLOTHING. RINSE SKIN WITH
WATER
IF INHALED:
REMOVE PERSON TO FRESH AIR AND KEEP COMFORTABLE FOR BREATHING. CALL A
POISON CENTER OR PHYSICIAN IF YOU FEEL UNWELL.
IF SWALLOWED: CALL A POISON CENTER OR PHYSICIAN IF YOU FEEL UNWELL
RINSE MOUTH
PRECAUTIONARY STATEMENTS - STORAGE:
STORE IN A WELL-VENTILATED PLACE. KEEP COOL
PRECAUTIONARY STATEMENTS - DISPOSAL:
DISPOSE OF CONTENTS AND CONTAINER TO AN APPROVED WASTE DISPOSAL PLANT IN
ACCORDANCE WITH LOCAL, REGIONAL, NATIONAL AND INTERNATIONAL REGULATIONS
AS APPLICABLE
| 3. COMPOSITION/INFORMATION ON INGREDIENTS | |
COMPONENT CAS NO WEIGHT-%
ACETONITRILE 75-05-8 100
| 4. FIRST AID MEASURES | |
FIRST AID MEASURES:
GENERAL ADVICE:
NATIONAL CAPITAL POISON CENTER IN THE UNITED STATES CAN PROVIDE ASSISTANCE
IF YOU HAVE A POISON EMERGENCY AND NEED TO TALK TO A POISON SPECIALIST.
CALL 1-800-222-1222. ENSURE THAT MEDICAL PERSONNEL ARE AWARE OF THE
MATERIAL(S) INVOLVED AND TAKE PRECAUTIONS TO PROTECT THEMSELVES. FIRST
AIDER NEEDS TO PROTECT HIMSELF.
SKIN CONTACT:
WASH OFF IMMEDIATELY WITH SOAP AND PLENTY OF WATER REMOVING ALL
CONTAMINATED CLOTHING AND SHOES. GET MEDICAL ATTENTION. IF SKIN IRRITATION
PERSISTS, CALL A PHYSICIAN.
EYE CONTACT: FLUSH EYES WITH WATER FOR 15 MINUTES. GET MEDICAL ATTENTION.
INHALATION:
MOVE TO FRESH AIR. IF BREATHING IS DIFFICULT, GIVE OXYGEN. IF NOT
BREATHING, GIVE ARTIFICIAL RESPIRATION. GET MEDICAL ATTENTION.
INGESTION:
DO NOT INDUCE VOMITING WITHOUT MEDICAL ADVICE. NEVER GIVE ANYTHING BY
MOUTH TO AN UNCONSCIOUS PERSON. OBTAIN MEDICAL ATTENTION.
MOST IMPORTANT SYMPTOMS AND EFFECTS, BOTH ACUTE AND DELAYED:
SYMPTOMS:
CENTRAL NERVOUS SYSTEM EFFECTS
DROWSINESS
DIZZINESS
HEADACHE
ATAXIA
CONVULSIONS
WEAKNESS
NAUSEA
VOMITING
MAY CAUSE CARDIOVASCULAR EFFECTS
MAY CAUSE METABOLIC ACIDOSIS
MAY AFFECT RESPIRATION
CAUSES SERIOUS EYE IRRITATION
MODERATE EYE IRRITATION
MILD TO MODERATE SKIN IRRITATION
INDICATION OF ANY IMMEDIATE MEDICAL ATTENTION AND SPECIAL TREATMENT NEEDED:
NOTES TO PHYSICIAN:
PATIENTS WITH A POTENTIAL INGESTION OR INHALATION EXPOSURE TO ACETONITRILE
OR PRODUCTS CONTAINING ACETONITRILE SHOULD BE ADMITTED TO AN INTENSIVE
CARE UNIT FOR AT LEAST 24 TO 48 HOURS OF OBSERVATION FOR THE DEVELOPMENT
OF CYANIDE POISONING. TOXICITY MAY BE PROLONGED. CLINICAL DETERIORATION
HAS BEEN REPORTED AS LONG AS 3 DAYS FOLLOWING THE INITIAL RESPONSE TO THE
ANTIDOTE TREATMENT.
ANTIDOTE:
ALWAYS HAVE A CYANIDE ANTIDOTE KIT ON HAND WHEN WORKING WITH ACETONITRILE
OR OTHER CYANIDE COMPOUNDS. GET MEDICAL ADVICE ON HOW TO USE IT AND WHEN
IT SHOULD BE USED.
PROTECTION OF FIRST-AIDERS:
FIRST-AID PROVIDERS:
AVOID EXPOSURE TO BLOOD OR BODY FLUIDS. WEAR GLOVES AND OTHER NECESSARY
PROTECTIVE CLOTHING. DISPOSE OF CONTAMINATED CLOTHING AND EQUIPMENT AS
BIO-HAZARDOUS WASTE.
| 5. FIRE-FIGHTING MEASURES | |
EXTINGUISHING MEDIA:
SUITABLE EXTINGUISHING MEDIA:
CARBON DIOXIDE (CO2). DRY CHEMICAL. ALCOHOL-RESISTANT FOAM. WATER SPRAY.
UNSUITABLE EXTINGUISHING MEDIA:
DO NOT USE A SOLID (STRAIGHT) WATER STREAM AS IT MAY SCATTER AND SPREAD
FIRE.
SPECIFIC HAZARDS ARISING FROM THE CHEMICAL:
HAZARDOUS COMBUSTION PRODUCTS:
CARBON MONOXIDE, CARBON DIOXIDE. NITROGEN OXIDES (NOX). HYDROGEN CYANIDE.
SPECIFIC HAZARDS:
FLAMMABLE. MAY BE IGNITED BY HEAT, SPARKS OR FLAMES. CONTAINER EXPLOSION
MAY OCCUR UNDER FIRE CONDITIONS OR WHEN HEATED. VAPOR MAY TRAVEL
CONSIDERABLE DISTANCE TO SOURCE OF IGNITION AND FLASH BACK. VAPORS MAY
FORM EXPLOSIVE MIXTURES WITH AIR. MOST VAPORS ARE HEAVIER THAN AIR. THEY
WILL SPREAD ALONG THE GROUND AND COLLECT IN LOW OR CONFINED AREAS (SEWERS,
BASEMENTS, TANKS). FIRE MAY PRODUCE IRRITATING, CORROSIVE AND/OR TOXIC
GASES.
SPECIAL PROTECTIVE ACTIONS FOR FIREFIGHTERS:
SPECIFIC METHODS: NO INFORMATION AVAILABLE
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS:
AS IN ANY FIRE, WEAR SELF-CONTAINED BREATHING APPARATUS PRESSURE-DEMAND,
MSHA/NIOSH (APPROVED OR EQUIVALENT) AND FULL PROTECTIVE GEAR
| 6. ACCIDENTAL RELEASE MEASURES | |
PERSONAL PRECAUTIONS, PROTECTIVE EQUIPMENT AND EMERGENCY PROCEDURES:
PERSONAL PRECAUTIONS:
ENSURE ADEQUATE VENTILATION. KEEP PEOPLE AWAY FROM AND UPWIND OF
SPILL/LEAK. AVOID CONTACT WITH SKIN, EYES AND CLOTHING. USE PERSONAL
PROTECTIVE EQUIPMENT. REMOVE ALL SOURCES OF IGNITION. PAY ATTENTION TO
FLASHBACK. TAKE PRECAUTIONARY MEASURES AGAINST STATIC DISCHARGES. ALL
EQUIPMENT USED WHEN HANDLING THE PRODUCT MUST BE GROUNDED. USE SPARK-PROOF
TOOLS AND EXPLOSION-PROOF EQUIPMENT. IN CASE OF LARGE SPILL, WATER SPRAY
OR VAPOR SUPPRESSING FOAM MAY BE USED TO REDUCE VAPORS, BUT MAY NOT PREVENT
IGNITION IN CLOSED SPACES.
ENVIRONMENTAL PRECAUTIONS:
PREVENT PRODUCT FROM ENTERING DRAINS. PREVENT FURTHER LEAKAGE OR SPILLAGE
IF SAFE TO DO SO. PREVENT ENTRY INTO WATERWAYS, SEWERS, BASEMENTS OR
CONFINED AREAS.
METHODS AND MATERIAL FOR CONTAINMENT AND CLEANING UP:
METHODS FOR CONTAINMENT:
STOP LEAK IF YOU CAN DO IT WITHOUT RISK. ABSORB SPILL WITH INERT MATERIAL
(E.G. VERMICULITE, DRY SAND OR EARTH). IN CASE OF LARGE SPILL, DIKE IF
NEEDED. DIKE FAR AHEAD OF LIQUID SPILL FOR LATER DISPOSAL.
METHODS FOR CLEANING UP:
USE APPROPRIATE TOOLS TO PUT THE SPILLED MATERIAL IN A SUITABLE CHEMICAL
WASTE DISPOSAL CONTAINER. USE ONLY NON-SPARKING TOOLS. CLEAN CONTAMINATED
SURFACE THOROUGHLY.
| 7. HANDLING AND STORAGE | |
PRECAUTIONS FOR SAFE HANDLING:
TECHNICAL MEASURES/PRECAUTIONS:
PROVIDE SUFFICIENT AIR EXCHANGE AND/OR EXHAUST IN WORK ROOMS. REMOVE ALL
SOURCES OF IGNITION. TO AVOID IGNITION OF VAPORS BY STATIC ELECTRICITY
DISCHARGE, ALL METAL PARTS OF THE EQUIPMENT MUST BE GROUNDED. KEEP AWAY
FROM INCOMPATIBLE MATERIALS.
SAFE HANDLING ADVICE:
WEAR PERSONAL PROTECTIVE EQUIPMENT. USE ONLY IN WELL-VENTILATED AREAS.
AVOID CONTACT WITH SKIN, EYES AND CLOTHING. KEEP AWAY FROM HEAT AND SOURCES
OF IGNITION. DO NOT BREATHE VAPORS OR SPRAY MIST. DO NOT INGEST. WHEN USING
DO NOT SMOKE. HANDLE IN ACCORDANCE WITH GOOD INDUSTRIAL HYGIENE AND SAFETY
PRACTICE.
CONDITIONS FOR SAFE STORAGE, INCLUDING ANY INCOMPATIBILITIES:
TECHNICAL MEASURES/STORAGE CONDITIONS:
KEEP CONTAINER TIGHTLY CLOSED IN A DRY AND WELL-VENTILATED PLACE. STORE AT
ROOM TEMPERATURE IN THE ORIGINAL CONTAINER. PROTECT FROM MOISTURE. KEEP
AWAY FROM HEAT AND SOURCES OF IGNITION. STORE IN A SEGREGATED AND APPROVED
AREA. STORE AWAY FROM INCOMPATIBLE MATERIALS.
INCOMPATIBLE MATERIALS:
OXIDIZING AGENTS
CHLORINE
FLUORINE
BROMINE
ACIDS
SULFURIC ACID
CHLOROSULFONIC ACID
NITRIC ACID
PERCHLORIC ACID
OLEUM
NITROGEN-FLUORINE COMPOUNDS
DINITROGEN TETRAOXIDE
| 8. EXPOSURE CONTROLS/PERSONAL PROTECTION | |
CONTROL PARAMETERS:
NATIONAL OCCUPATIONAL EXPOSURE LIMITS:
UNITED STATES:
COMPONENT CAS NO OSHA NIOSH ACGIH AIHA WEEL
ACETONITRILE 75-05-8 40 PPM TWA 20 PPM TWA 20 PPM TWA NONE
70 MG/M3 TWA 34 MG/M3 TWA
CANADA:
COMPONENT CAS NO CANADA - CANADA - CANADA - CANADA -
ALBERTA BRITISH ONTARIO QUEBEC
COLUMBIA
ACETONITRILE 75-05-8 20 PPM TWA 20 PPM TWA NONE 40 PPM TWAEV
34 MG/M3 TWA 67 MG/M3 TWAEV
60 PPM STEV
101 MG/M3 STEV
AUSTRALIA AND MEXICO:
COMPONENT CAS NO AUSTRALIA MEXICO
ACETONITRILE 75-05-8 60 PPM STEL 40 PPM TWA
101 MG/M3 STEL 70 MG/M3 TWA
40 PPM TWA 60 PPM STEL
67 MG/M3 TWA 105 MG/M3 STEL
APPROPRIATE ENGINEERING CONTROLS:
ENGINEERING MEASURES TO REDUCE EXPOSURE:
ENSURE ADEQUATE VENTILATION. PROVIDE EXHAUST VENTILATION OR OTHER
ENGINEERING CONTROLS TO KEEP THE AIRBORNE CONCENTRATIONS OF VAPORS
AND MIST BELOW THEIR RESPECTIVE THRESHOLD LIMIT VALUE.
INDIVIDUAL PROTECTION MEASURES, SUCH AS PERSONAL PROTECTIVE EQUIPMENT:
PERSONAL PROTECTIVE EQUIPMENT:
EYE PROTECTION: GOGGLES
SKIN AND BODY PROTECTION:
CHEMICAL RESISTANT APRON
LONG SLEEVED CLOTHING
GLOVES
RESPIRATORY PROTECTION:
VAPOR RESPIRATOR. BE SURE TO USE AN APPROVED/CERTIFIED RESPIRATOR
OR EQUIVALENT.
HYGIENE MEASURES:
AVOID CONTACT WITH SKIN, EYES AND CLOTHING. WHEN USING, DO NOT EAT, DRINK
OR SMOKE. WASH HANDS BEFORE BREAKS AND IMMEDIATELY AFTER HANDLING THE
PRODUCT
| 9. PHYSICAL AND CHEMICAL PROPERTIES | |
PHYSICAL STATE: LIQUID
APPEARANCE: NO INFORMATION AVAILABLE.
COLOR: CLEAR. COLORLESS.
ODOR: AROMATIC. SWEET. ETHEREAL.
TASTE: BURNING. SWEETISH.
FORMULA: CH3CN
MOLECULAR/FORMULA WEIGHT (G/MOLE): 41.05
FLAMMABILITY (SOLID, GAS): NO DATA AVAILABLE
FLASH POINT (DEG. C): 5.56
FLASHPOINT (DEG. C/DEG. F):
12.778 DEG. C/55 DEG. F
5.56 DEG. C/42 DEG. F
FLASH POINT TESTED ACCORDING TO:
CLOSED CUP
OPEN CUP
AUTOIGNITION TEMPERATURE (DEG. C/DEG. F): 524 DEG. C/975 DEG. F
LOWER EXPLOSION LIMIT (%): 3%
UPPER EXPLOSION LIMIT (%): 16%
MELTING POINT/RANGE(DEG. C/DEG. F): -45 TO -46 DEG. C/-49 TO -50.8 DEG. F
DECOMPOSITION TEMPERATURE(DEG. C/DEG. F): NO INFORMATION AVAILABLE
BOILING POINT/RANGE(DEG. C/DEG. F): 81.6 DEG. C/178.9 DEG. F
BULK DENSITY: NO INFORMATION AVAILABLE
DENSITY (G/CM3): NO INFORMATION AVAILABLE
SPECIFIC GRAVITY: 0.78-0.79
PH: NO INFORMATION AVAILABLE
VAPOR PRESSURE @ 20 DEG. C (KPA): 9.73
EVAPORATION RATE: NO INFORMATION AVAILABLE
VAPOR DENSITY: 1.42
VOC CONTENT (G/L): 780-790
ODOR THRESHOLD (PPM): 40
PARTITION COEFFICIENT (N-OCTANOL/WATER): -0.34
VISCOSITY: NO INFORMATION AVAILABLE
MISCIBILITY:
MISCIBLE WITH METHANOL
MISCIBLE WITH ETHANOL
MISCIBLE WITH ETHER
MISCIBLE WITH ACETONE
MISCIBLE WITH BENZENE
MISCIBLE WITH CARBON TETRACHLORIDE
MISCIBLE WITH ETHYL ACETATE
SOLUBILITY:
FREELY SOLUBLE IN WATER
SOLUBLE IN HOT ALCOHOL
DISSOLVES SOMEWHAT IN INORGANIC SALTS
SUCH AS SILVER NITRATE, LITHIUM NITRATE, MAGNESIUM BROMIDE
MISCIBLE WITH CHLOROFORM
MISCIBLE WITH ETHYLENE CHLORIDE
MISCIBLE WITH MANY UNSATURATED
HYDROCARBONS
IMMISCIBLE WITH MANY SATURATED HYDROCARBONS
EQUAL WEIGHT OF ACETONITRILE AND THE FOLLOWING MATERIALS ARE MISCIBLE AT
ROOM TEMP:
FORMIC ACID, ACETIC ACID, LEVULINIC ACID, METHANOL, CELLOSOLVE SOLVENT,
FORMALDEHYDE, ACETALDEHYDE, DI-N-BUTYL AMINE, ACETIC ANHYDRIDE, PYRIDINE,
NITROBENZENE, ANILINE, XYLENE, PHENOL, ACETYL CHLORIDE, DIBUTYL PHTHALATE,
DIGLYCOL STEARATE, N-BUTYL ETHER, DICHLOROETHYL ETHER, METHYL ISOBUTYL
KETONE, NITROMETHANE, NITROETHANE, NITROPROPANE
MISCIBLE WITH METHANOL
MISCIBLE WITH METHYL ACETATE
| 10. STABILITY AND REACTIVITY | |
REACTIVITY:
WILL REACT WITH WATER, STEAM, OR ACIDS TO PRODUCE TOXIC AND FLAMMABLE
VAPORS
REACTIVE WITH OXIDIZING AGENTS
REACTIVE WITH ACIDS
REACTS WITH NITROGEN-FLUORINE COMPOUNDS
REACTS WITH DINITROGEN TETRAOXIDE
CHEMICAL STABILITY:
STABILITY: STABLE UNDER RECOMMENDED STORAGE CONDITIONS.
POSSIBILITY OF HAZARDOUS REACTIONS: HAZARDOUS POLYMERIZATION DOES NOT OCCUR
CONDITIONS TO AVOID:
HEAT. IGNITION SOURCES. INCOMPATIBLE MATERIALS. EXPOSURE TO MOISTURE.
EXPOSURE TO WATER.
INCOMPATIBLE MATERIALS:
OXIDIZING AGENTS
CHLORINE
FLUORINE
BROMINE
ACIDS
SULFURIC ACID
CHLOROSULFONIC ACID
NITRIC ACID
PERCHLORIC ACID
OLEUM
NITROGEN-FLUORINE COMPOUNDS
DINITROGEN TETRAOXIDE
HAZARDOUS DECOMPOSITION PRODUCTS:
CARBON MONOXIDE. CARBON DIOXIDE. HYDROGEN CYANIDE (HYDROCYANIC ACID).
NITROGEN OXIDES (NOX). WHEN HEATED TO DECOMPOSITION IT EMITS HIGHLY TOXIC
FUMES.
OTHER INFORMATION:
CORROSIVITY: NO INFORMATION AVAILABLE
SPECIAL REMARKS ON CORROSIVITY: NO INFORMATION AVAILABLE
| 11. TOXICOLOGICAL INFORMATION | |
INFORMATION ON LIKELY ROUTES OF EXPOSURE:
PRINCIPAL ROUTES OF EXPOSURE: INGESTION. SKIN. EYES. INHALATION.
ACUTE TOXICITY:
COMPONENT INFORMATION:
ACETONITRILE:
CAS NO: 75-05-8
LD50/ORAL/RAT:
160 MG/KG ORAL LD50 RAT
2460 MG/KG ORAL LD50 RAT (LOLI)
4891 MG/KG (RTECS)
1327-6762 MG/KG (EUROPEAN CHEMICAL BUREAU IUCLID DATASET)
LD50/ORAL/MOUSE: 269 MG/KG (RTECS)
LD50/DERMAL/RABBIT:
>2000 MG/KG DERMAL LD50 RABBIT(LOLI)
1250 MG/KG (EUROPEAN CHEMICAL BUREAU IUCLID DATASET)
980 MG/KG (RTECS)
LD50/DERMAL/RAT: 390 MG/KG DERMAL LD50 RAT
LC50/INHALATION/RAT:
7551 PPM INHALATION LC50 RAT 8 H
26.8 MG/L INHALATION LC50 4 H
LC50/INHALATION/MOUSE: 2693 PPM 1H
OTHER LD50 OR LC50INFORMATION:
5655 PPM 4 H INHALATION LC50 (GUINEA PIG)
2828 PPM 4 H INHALATION LC50 (RABBIT)
PRODUCT INFORMATION:
LD50/ORAL/RAT:
VALUE-ACUTE TOXICITY: 1327 MG/KG
LD50/ORAL/MOUSE:
VALUE-ACUTE TOX: 269 MG/KG
LD50/DERMAL/RABBIT:
VALUE-ACUTE TOXICITY: 1250 MG/KG
LD50/DERMAL/RAT:
VALUE-ACUTE TOX: NO INFORMATION AVAILABLE
LC50/INHALATION/RAT:
VALUE-VAPOR: 26.8 MG/L (4-HR)
VALUE-GAS: 16000 PPM (4-HR)
VALUE-DUST/MIST: NO INFORMATION AVAILABLE
LC50/INHALATION/MOUSE:
VALUE-VAPOR: NO INFORMATION AVAILABLE
VALUE-GAS: 2693 PPM 1H
VALUE-DUST/MIST: NO INFORMATION AVAILABLE
SYMPTOMS:
SKIN CONTACT:
MILDLY TO MODERATELY IRRITATING TO THE SKIN. HARMFUL IN CONTACT WITH SKIN.
IT MAY BE ABSORBED THROUGH THE SKIN. IF ABSORBED THROUGH SKIN IT MAY CAUSE
SYSTEMIC EFFECTS. IT MAY BE ABSORBED THROUGH THE SKIN AND CAUSE SYMPTOMS
SIMILAR TO CYANIDE POISONING. IT MAY BE METABOLIZED TO CYANIDE WHICH
INHIBITS CYTOCHROME OXIDASE THUS IMPAIRING CELLULAR RESPIRATION.
EYE CONTACT: CAUSES SERIOUS EYE IRRITATION.
INHALATION:
MAY CAUSE IRRITATION OF RESPIRATORY TRACT. IT MAY CAUSE PULMONARY EDEMA.
MAY CAUSE BRONCHITIS. MAY CAUSE PNEUMONIA. MAY CAUSE GASTRIC DISTRESS.
MAY CAUSE NAUSEA, VOMITING. MAY CAUSE SALIVATION. IT MAY BE METABOLIZED TO
CYANIDE WHICH INHIBITS CYTOCHROME OXIDASE THUS IMPAIRING CELLULAR
RESPIRATION. IT MAY CAUSE SYMPTOMS SIMILAR TO CYANIDE POISONING (SEE ACUTE
INGESTION FOR SYMPTOMS). MAY AFFECT THE KIDNEYS. IT MAY AFFECT THE URINARY
SYSTEM. IT MAY AFFECT RESPIRATION (ANOXIA, HYPOXIA, RESPIRATORY
INSUFFICIENCY, RESPIRATORY ARREST). IT MAY AFFECT THE CARDIOVASCULAR SYSTEM
(HYPOTENSION, CARDIAC ARRHYTHMIAS, CARDIAC ARREST). OTHER SYMPTOMS OF ACUTE
INHALATION MAY INCLUDE FLUSHING OF THE FACE, SWEATING, WEAKNESS, CHEST
PAIN/CHEST TIGHTNESS, VOMITING OF BLOOD, CONVULSIONS, SHOCK,
UNCONSCIOUSNESS, COMA/EXCITEMENT ALTERNATING WITH COMA. MAY CAUSE CORNEAL
OPACITY.
INGESTION:
HARMFUL IF SWALLOWED. INGESTION MAY CAUSE NAUSEA, VOMITING. MAY CAUSE
FLUSHING OF THE FACE. MAY CAUSE HEMATEMESIS. INGESTION MAY CAUSE SYMPTOMS
SIMILAR TO CYANIDE POISONING. IT MAY BE METABOLIZED TO CYANIDE WHICH
INHIBITS CYTOCHROME OXIDASE THUS IMPAIRING CELLULAR RESPIRATION. CYANIDE
POISONING IS CHARACTERIZED BY CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR
SYSTEM, AND RESPIRATORY SYSTEM EFFECTS SUCH AS GENERAL WEAKNESS, GIDDINESS,
CONFUSION, SLEEPINESS, HEADACHE, DIZZINESS, VERTIGO, SEIZURES, ATAXIA,
TETANY, IRRITABILITY, STUPOR, ANXIETY, HALLUCINATIONS, AGITATION, TREMORS,
UNCONCIOUNESS, COMA, PALPITATIONS, CARDIAC ARRHYTHMIAS, SLOW OR RAPID
HEARTBEAT, HYPERTENSION OR HYPOTENSION, PERCEIVED BREATHING DIFFICULTY AND
SHORTNESS OF BREATH, HYPERVENTILATION, ASPHYXIATION/RESPIRATORY FAILURE.
OTHER SYMPTOMS MAY INCLUDE EXCITEMENT, CHEST PAIN, CHEST TIGHTNESS, ANOXIA,
HYPOXIA, SHORTNESS OF BREATH, CARDIAC ARREST. MAY CAUSE METABOLIC ACIDOSIS.
MAY CAUSE LACTIC ACIDOSIS.
ASPIRATION HAZARD: NO INFORMATION AVAILABLE.
DELAYED AND IMMEDIATE EFFECTS AS WELL AS CHRONIC EFFECTS FROM SHORT AND
LONG-TERM EXPOSURE:
CHRONIC TOXICITY:
PROLONGED OR REPEATED INHALATION MAY CAUSE LOSS OF APPETITE. PROLONGED OR
REPEATED INGESTION MAY CAUSE LOSS OF APPETITE. REPEATED OR PROLONGED
INGESTION MAY AFFECT THE BLOOD. PROLONGED OR REPEATED INGESTION MAY
AFFECT THE KIDNEYS. PROLONGED OR REPEATED INGESTION MAY AFFECT THE LIVER.
PROLONGED OR REPEATED INHALATION MAY AFFECT THE LIVER. PROLONGED OR
REPEATED INHALATION MAY AFFECT THE KIDNEYS. PROLONGED OR REPEATED INGESTION
MAY AFFECT THE THYROID (HYPERPLASIA/ENLARGMENT). PROLONGED OR REPEATED
INHALATION MAY AFFECT THE BLOOD (CHANGES IN RED BLOOD CELL COUNT).
PROLONGED OR REPEATED INHALATION MAY CAUSE CENTRAL NERVOUS SYSTEM EFFECTS.
SENSITIZATION: NO INFORMATION AVAILABLE.
MUTAGENIC EFFECTS: MAY AFFECT GENETIC MATERIAL
SISTER CHROMATID EXCHANGE: HAMSTER OVARY (RTECS)
CARCINOGENIC EFFECTS:
NOT CLASSIFIABLE AS A HUMAN CARCINOGEN. MAY CAUSE CANCER BASED ON ANIMAL
TEST DATA. EQUIVOCAL TUMORIGENIC AGENT BY RTECS CRITERIA.
COMPONENT CAS NO IARC ACGIH - NTP
CARCINOGENS
ACETONITRILE 75-05-8 NOT LISTED A4 NOT NOT LISTED
CLASSIFIABLE
AS A HUMAN
CARCINOGEN
COMPONENT OSHA HCS - AUSTRALIA - AUSTRALIA -
CARCINOGENS NOTIFIABLE PROHIBITED
CARCINOGENIC CARCINOGENIC
SUBSTANCES SUBSTANCES
ACETONITRILE NOT LISTED NOT LISTED NOT LISTED
ACGIH (AMERICAN CONFERENCE OF GOVERNMENTAL INDUSTRIAL HYGIENISTS):
A4 - NOT CLASSIFIABLE AS A HUMAN CARCINOGEN
IARC (INTERNATIONAL AGENCY FOR RESEARCH ON CANCER):
NTP (NATIONAL TOXICOLOGY PROGRAM):
OSHA (OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION OF THE US DEPARTMENT
OF LABOR):
REPRODUCTIVE TOXICITY NO DATA IS AVAILABLE
REPRODUCTIVE EFFECTS: NO INFORMATION AVAILABLE
DEVELOPMENTAL EFFECTS: NO INFORMATION AVAILABLE
TERATOGENIC EFFECTS:
MAY CAUSE BIRTH DEFECTS (TERATOGENIC EFFECTS) BASED ON ANIMAL TEST DATA
SHOWED TERATOGENIC EFFECTS IN ANIMAL EXPERIMENTS
SPECIFIC TARGET ORGAN TOXICITY:
STOT - SINGLE EXPOSURE NO INFORMATION AVAILABLE.
STOT - REPEATED EXPOSURE NO INFORMATION AVAILABLE.
TARGET ORGANS:
BLOOD. LIVER. KIDNEYS. CENTRAL NERVOUS SYSTEM. RESPIRATORY SYSTEM. LUNGS.
THYROID.
| 12. ECOLOGICAL INFORMATION | |
ECOTOXICITY:
ECOTOXICITY EFFECTS: AQUATIC ENVIRONMENT.
ACETONITRILE - 75-05-8:
FISH:
LC50: 1600 - 1690 MG/L (96H, PIMEPHALES PROMELAS)
LC50: =1000 MG/L (96H, PIMEPHALES PROMELAS)
LC50: =1850 MG/L (96H, LEPOMIS MACROCHIRUS)
LC50: =1650 MG/L (96H, POECILIA RETICULATA)
CRUSTACEA EC50: =5838 MG/L (18H, DAPHNIA PULEX)
PERSISTENCE AND DEGRADABILITY: NO INFORMATION AVAILABLE
BIOACCUMULATIVE POTENTIAL: NO INFORMATION AVAILABLE.
MOBILITY IN SOIL: NO INFORMATION AVAILABLE
OTHER ADVERSE EFFECTS: NO INFORMATION AVAILABLE.
| 13. DISPOSAL CONSIDERATIONS | |
DISPOSAL METHODS:
WASTE FROM RESIDUES / UNUSED PRODUCTS:
WASTE MUST BE DISPOSED OF IN ACCORDANCE WITH FEDERAL, STATE AND LOCAL
REGULATION.
CONTAMINATED PACKAGING:
EMPTY CONTAINERS SHOULD BE TAKEN FOR LOCAL RECYCLING, RECOVERY OR WASTE
DISPOSAL
COMPONENT CAS NO RCRA - F RCRA - K RCRA - P RCRA - U
SERIES SERIES SERIES SERIES
WASTES WASTES WASTES WASTES
ACETONITRILE 75-05-8 NONE NONE NONE U003 IGNITABLE
WASTE, TOXIC
WASTE
| 14. TRANSPORT INFORMATION | |
DOT:
UN-NO: UN1648
PROPER SHIPPING NAME: ACETONITRILE
HAZARD CLASS: 3
SUBSIDIARY CLASS: NO INFORMATION AVAILABLE
PACKING GROUP: II
EMERGENCY RESPONSE GUIDE NUMBER: 127
MARINE POLLUTANT: NO DATA AVAILABLE
DOT RQ (LBS): 5000 LBS./2270 KG
SPECIAL PROVISIONS: IB2, T7, TP2
SYMBOL(S) [DOT]:
(R5) - IDENTIFIES A MATERIAL THAT IS A HAZARDOUS SUBSTANCE THAT HAS A
REPORTABLE QUANTITY (RQ) OF 5000 POUNDS (2270 KILOGRAMS).
DESCRIPTION: UN1648, ACETONITRILE, 3, II
TDG (CANADA):
UN-NO: UN1648
PROPER SHIPPING NAME: ACETONITRILE
HAZARD CLASS: 3
SUBSIDIARY RISK: NO INFORMATION AVAILABLE
PACKING GROUP: II
MARINE POLLUTANT: NO INFORMATION AVAILABLE
DESCRIPTION: UN1648, ACETONITRILE, 3, II
ADR:
UN NUMBER: UN1648
PROPER SHIPPING NAME: ACETONITRILE
TRANSPORT HAZARD CLASS(ES): 3
PACKING GROUP: II
SUBSIDIARY RISK: NO INFORMATION AVAILABLE
DESCRIPTION: UN1648, ACETONITRILE, 3, II
IMDG:
UN-NO: UN1648
PROPER SHIPPING NAME: ACETONITRILE
HAZARD CLASS: 3
SUBSIDIARY RISK: NO INFORMATION AVAILABLE
PACKING GROUP: II
MARINE POLLUTANT: NO INFORMATION AVAILABLE
EMS: F-E
DESCRIPTION: UN1648, ACETONITRILE, 3, II
RID:
UN NUMBER: UN1648
PROPER SHIPPING NAME: ACETONITRILE
TRANSPORT HAZARD CLASS(ES): 3
SUBSIDIARY RISK: 3
PACKING GROUP: II
DESCRIPTION: UN1648, ACETONITRILE, 3, II
ICAO (AIR):
UN-NO: UN1648
PROPER SHIPPING NAME: ACETONITRILE
HAZARD CLASS: 3
SUBSIDIARY RISK: NO INFORMATION AVAILABLE
PACKING GROUP: II
DESCRIPTION: UN1648, ACETONITRILE, 3, II
IATA:
UN NUMBER: UN1648
PROPER SHIPPING NAME: ACETONITRILE
TRANSPORT HAZARD CLASS(ES): 3
SUBSIDIARY RISK: NO INFORMATION AVAILABLE
PACKING GROUP: II
PRECAUTIONARY STATEMENTS - RESPONSE: 3L
SPECIAL PROVISIONS: NO INFORMATION AVAILABLE
DESCRIPTION: UN1648, ACETONITRILE, 3, II
| 15. REGULATORY INFORMATION | |
INTERNATIONAL INVENTORIES:
COMPONENT CAS NO U.S. TSCA KOREA KECL PHILIPPINES (PICCS)
ACETONITRILE 75-05-8 PRESENT PRESENT PRESENT
ACTIVE KE-00067
COMPONENT JAPAN ENCS CHINA IECSC AUSTRALIA (AICS) EINECS-NO.
ACETONITRILE PRESENT PRESENT PRESENT PRESENT
(2)-1508 200-835-2
U.S. REGULATIONS:
ACETONITRILE:
MASSACHUSETTS RTK: PRESENT
NEW JERSEY RTK HAZARDOUS SUBSTANCE LIST: 0008
NEW JERSEY (EHS) LIST: 0008 500 LB TPQ
NEW JERSEY - DISCHARGE PREVENTION - LIST OF HAZARDOUS SUBSTANCES: PRESENT
PENNSYLVANIA RTK: ENVIRONMENTAL HAZARD
PENNSYLVANIA RTK - ENVIRONMENTAL HAZARD LIST PRESENT
MINNESOTA - HAZARDOUS SUBSTANCE LIST: PRESENT
NEW YORK RELEASE REPORTING - LIST OF HAZARDOUS SUBSTANCES:
5000 LB RQ
1 LB RQ
LOUISANA REPORTABLE QUANTITY LIST FOR POLLUTANTS:
5000 LB FINAL RQ
2270 KG FINAL RQ
CALIFORNIA DIRECTORS LIST OF HAZARDOUS SUBSTANCES: PRESENT
CALIFORNIA PROP. 65: SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986.
CHEMICALS KNOWN TO THE STATE OF CALIFORNIA TO CAUSE CANCER:
THIS PRODUCT DOES NOT CONTAIN A CHEMICAL REQUIRING A WARNING UNDER
CALIFORNIA PROP. 65. (SEE TABLE BELOW)
CHEMICALS KNOWN TO THE STATE OF CALIFORNIA TO CAUSE REPRODUCTIVE TOXICITY:
THIS PRODUCT DOES NOT CONTAIN A CHEMICAL REQUIRING A WARNING UNDER
CALIFORNIA PROP. 65. (SEE TABLE BELOW)
COMPONENT CAS NO CARCINOGEN DEVELOPMENTAL TOXICITY
ACETONITRILE 75-05-8 NOT LISTED NOT LISTED
COMPONENT MALE REPRODUCTIVE TOXICITY FEMALE REPRODUCTIVE TOXICITY
ACETONITRILE NOT LISTED NOT LISTED
CERCLA/SARA:
COMPONENT CAS NO CERCLA - HAZARDOUS SECTION 302 EXTREMELY
SUBSTANCES AND THEIR HAZARDOUS SUBSTANCES
REPORTABLE QUANTITIES AND TPQS
ACETONITRILE 75-05-8 5000 LB FINAL RQ NONE
2270 KG FINAL RQ
COMPONENT SECTION 302 SECTION 313 - SECTION 313 -
EXTREMELY CHEMICAL CATEGORY REPORTING
HAZARDOUS DE MINIMIS
SUBSTANCES
AND RQS
ACETONITRILE NONE NONE 1.0% DE MINIMIS
CONCENTRATION
U.S. TSCA:
COMPONENT CAS NO TSCA SECTION 5(A)2 - TSCA 8(D) - HEALTH AND
CHEMICALS WITH SAFETY REPORTING
SIGNIFICANT NEW
USE RULES (SNURS)
ACETONITRILE 75-05-8 NOT APPLICABLE NOT APPLICABLE
CANADA:
WHIMIS 2015 - GHS CLASSIFICATIONS:
WHMIS 2015 HAZARD CLASSIFICATION INFORMATION:
COMPONENT: ACETONITRILE 75-05-8 (100)
WHMIS 2015 HAZARD CLASSIFICATION
FLAMMABLE LIQUIDS - CATEGORY 2:
H225: HIGHLY FLAMMABLE LIQUID AND VAPOUR.
ACUTE TOXICITY - ORAL - CATEGORY 3:
H301: TOXIC IF SWALLOWED.
ACUTE TOXICITY - DERMAL - CATEGORY 4:
H312: HARMFUL IN CONTACT WITH SKIN.
ACUTE TOXICITY - INHALATION - CATEGORY 3:
H331: TOXIC IF INHALED.
SERIOUS EYE DAMAGE/EYE IRRITATION - CATEGORY 2A:
H319: CAUSES SERIOUS EYE IRRITATION.
CANADA HAZARDOUS PRODUCTS REGULATION:
THIS PRODUCT HAS BEEN CLASSIFIED ACCORDING TO THE HAZARD CRITERIA OF THE
HPR (HAZARDOUS PRODUCTS REGULATION) AND THE SDS CONTAINS ALL OF THE
INFORMATION REQUIRED BY THE HPR
DSL/NDSL:
COMPONENT CAS NO CANADA (DSL) CANADA (NDSL)
ACETONITRILE 75-05-8 PRESENT NOT LISTED
COMPONENT CAS NO CEPA SCHEDULE I - TOXIC SUBSTANCES
ACETONITRILE 75-05-8 NOT LISTED
COMPONENT CAS NO CEPA - 2010 GREENHOUSE GASES SUBJECT TO
MANDATORY REPORTING
ACETONITRILE 75-05-8 NOT LISTED
EU CLASSIFICATION:
EU GHS - SV - CLP 1272/2008:
COMPONENT CAS NO EU GHS - SV - CLP (1272/2008)
ACETONITRILE 75-05-8 FLAMMABLE LIQUIDS - FLAM. LIQ. 2:
H225: HIGHLY FLAMMABLE LIQUID AND VAPOUR.
ACUTE TOXICITY - ORAL - ACUTE TOX. 4:
H302:
HARMFUL IF SWALLOWED. (MINIMUM CLASSIFICATION)
ACUTE TOXICITY - DERMAL - ACUTE TOX. 4:
H312:
HARMFUL IN CONTACT WITH SKIN. (MINIMUM
CLASSIFICATION)
ACUTE TOXICITY - INHALATION - ACUTE TOX. 4:
H332: HARMFUL IF INHALED. (MINIMUM CLASSIFICATION)
SERIOUS EYE DAMAGE/EYE IRRITATION - EYE IRRIT. 2:
H319:
CAUSES SERIOUS EYE IRRITATION. 608-001-00-3
EU - CLP (1272/2008):
R-PHRASE(S):
R11: HIGHLY FLAMMABLE R36 - IRRITATING TO EYES
R20/21/22:
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED
S-PHRASE(S):
S16: KEEP AWAY FROM SOURCES OF IGNITION - NO SMOKING
S36/37: WEAR SUITABLE PROTECTIVE CLOTHING AND GLOVES
COMPONENT CAS NO CLASSIFICATION CONCENTRATION SAFETY PHRASES
LIMITS
ACETONITRILE 75-05-8 F; R11 NO INFORMATION S2 S16 S36/37
XN; R20/21/22
XI; R36
THE PRODUCT IS CLASSIFIED IN ACCORDANCE WITH ANNEX VI TO DIRECTIVE
67/548/EEC:
INDICATION OF DANGER:
F - HIGHLY FLAMMABLE
XN - HARMFUL
XI - IRRITANT
| 16. OTHER INFORMATION | |
PREPARATION DATE: 1/17/2014
REVISION DATE: 6/6/2019
PREPARED BY: SONIA OWEN
DISCLAIMER:
ALL CHEMICALS MAY POSE UNKNOWN HAZARDS AND SHOULD BE USED WITH CAUTION.
THIS SAFETY DATA SHEET (SDS) APPLIES ONLY TO THE MATERIAL AS PACKAGED.
IF THIS PRODUCT IS COMBINED WITH OTHER MATERIALS, DETERIORATES, OR BECOMES
CONTAMINATED, IT MAY POSE HAZARDS NOT MENTIONED IN THIS SDS. THE PHYSICAL
PROPERTIES REPORTED IN THIS SDS ARE OBTAINED FROM THE LITERATURE AND DO
NOT CONSTITUTE PRODUCT SPECIFICATIONS. INFORMATION CONTAINED HEREIN DOES
NOT CONSTITUTE A WARRANTY, WHETHER EXPRESSED OR IMPLIED, AS TO THE SAFETY,
MERCHANTABILITY OR FITNESS OF THE GOODS FOR A PARTICULAR PURPOSE. SPECTRUM
CHEMICALS & LABORATORY PRODUCTS, INC. ASSUMES NO RESPONSIBILITY FOR RESULTS
OBTAINED OR FOR INCIDENTAL OR CONSEQUENTIAL DAMAGES, INCLUDING LOST
PROFITS, ARISING FROM THE USE OF THESE DATA. NO WARRANTY AGAINST
INFRINGEMENT OF ANY PATENT, COPYRIGHT OR TRADEMARK IS MADE OR IMPLIED.
IT SHALL BE THE USER'S RESPONSIBILITY TO DEVELOP PROPER METHODS OF HANDLING
AND PERSONAL PROTECTION BASED ON THE ACTUAL CONDITIONS OF USE. WHILE THIS
SDS IS BASED ON TECHNICAL DATA JUDGED TO BE RELIABLE, SPECTRUM ASSUMES NO
RESPONSIBILITY FOR THE COMPLETENESS OR ACCURACY OF THE INFORMATION
CONTAINED HEREIN.